منابع مشابه
The Chemistry of Signal Transduction in the TetR System
Signal transduction proteins in biological systems must be very flexible to undergo the allosteric changes necessary for their function. It is current practice to investigate the modes of action of these systems by X-ray spectroscopy of the different states trapped as crystals. Unfortunately, the forces acting on the proteins by packing effects may lead to distortions comparable to the changes ...
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This issue of Breast Disease focuses on the subject of signal transduction and its role in the pathogenesis and progression of human breast cancer. Within the past 10 years, the explosion in our knowledge of these processes has significantly altered our understanding of breast cancer, and resulted in the first receptor-based therapies. This issue examines a variety of relevant signaling pathway...
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Cells respond to their environment by sensing signals and translating them into changes in gene expression. In recent years, synthetic networks have been designed in both prokaryotic and eukaryotic systems to create new functionalities and for specific applications. In this review, we discuss the challenges associated with engineering signal transduction pathways. Furthermore, we address advant...
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The band 4.1 domain was first identified in the red blood cell protein band 4.1, and subsequently in ezrin, radixin, and moesin (ERM proteins) and other proteins, including tumor suppressor merlin/schwannomin, talin, unconventional myosins VIHa and X, and protein tyrosine phosphatases. Recently, the presence of a structurally related domain has been demonstrated in the N-terminal region of two ...
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Functional immune responses evolve through an exquisitely controlled process integrating signals from activating and inhibitory receptors on the immune cell surface. These complex interactions, which regulate both the quality and magnitude of the ultimate response, depend crucially on two short, loosely conserved motifs found in the intracellular domain of various signaling proteins. These moti...
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ژورنال
عنوان ژورنال: Science
سال: 2002
ISSN: 0036-8075,1095-9203
DOI: 10.1126/science.298.5597.1301b